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VOLUME 1 , ISSUE 1 ( January-March, 2019 ) > List of Articles


Tuberculosis: Natural History

NC Gowrishankar

Keywords : Extrapulmonary, Infection, M. tuberculosis, Pulmonary

Citation Information : Gowrishankar N. Tuberculosis: Natural History. Pediatr Inf Dis 2019; 1 (1):4-6.

DOI: 10.5005/jp-journals-10081-1102

License: CC BY-NC 4.0

Published Online: 01-03-2019

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Tuberculosis is a scourge of mankind. The prechemotherapeutic era has given insights into the much needed natural history of tuberculosis. Once the TB bacilli enter the system, many factors including the age, nutritional status, the host immunity, bacillary load, pathogenicity of TB bacilli and HIV status tilt the balance between infection and disease. A clear understanding of the natural history helps us understand the various presentations in both pulmonary and extrapulmonary tuberculosis.

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  1. History of TB drugs - PAS, Streptomycin, Waksman. accessed on 30th Dec 2018)
  2. Bass JB Jr. B. The Tuberculin Skin Test. Tuberculosis in the Workplace. Institute of Medicine (US) Committee on Regulating Occupational Exposure to Tuberculosis; Field MJ, editor. Washington (DC): National Academies Press (US); 2001: pp 179- 188.
  3. Wallgren A. Primary pulmonary tuberculosis in childhood. Am J Dis Child 1935;49:1105-1136.
  4. Marais BJ, Gie RP, Schaaf HS, et al. The natural history of childhood intra-thoracic tuberculosis—A critical review of the prechemotherapy literature. Int J Tuberc Lung Dis 2004;8:392-402.
  5. Vijayasekeran D, Subramanyam L. Childhood tuberculosis. In Essentials of Pediatric Pulmonology. Ed Subramanyam L. 3rd Edition. Pediatric Pulmonnology Foundation of India, Chennai 2008; pp. 201-210.
  6. Donald PR, Marais BJ, Barry CE III. The influence of age on the epidemiology and pathology of tuberculosis. Lancet 2010;375:1852-1854.
  7. Marais BJ, Donald PR, Gie RP, et al. Diversity of disease manifestations in childhood pulmonary tuberculosis. Ann Trop Paediatr 2005;25:79-86
  8. Piccini P, Chiappini E, Tortoli E, et al. Clinical peculiarities of tuberculosis. BMC Infectious Diseases 2014
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