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VOLUME 1 , ISSUE 1 ( January-March, 2019 ) > List of Articles

REVIEW ARTICLE

Utility of Mantoux and Interferon-gamma Release Assays

Dhanya Dharmapalan

Keywords : Mantoux, Interferon-gamma release assays, Tuberculosis

Citation Information : Dharmapalan D. Utility of Mantoux and Interferon-gamma Release Assays. Pediatr Inf Dis 2019; 1 (1):17-18.

DOI: 10.5005/jp-journals-10081-1104

License: CC BY-NC 4.0

Published Online: 01-03-2019

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

India has the highest burden of tuberculosis (TB). This article presents a review of the diagnostic utility and various limitations of the Mantoux and the interferon-gamma release assays (IGRA) tests in this high TB endemic setting. While both the tests cannot differentiate between latent and active TB, recent guidelines from WHO strongly recommends against the use of IGRA as an alternative to Mantoux test for India.


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  1. Central Tuberculisis Division, GOI. National Guidelines in treatment and management of Pediatric Tuberculosis. Available from: https://tbcindia.gov.in/index1.php?sublinkid=4200&level=2&lid=2848&lang=1. Accessed on Jan 10, 2019.
  2. Pai M, Denkinger CM, Kik SV, et al. Gamma interferon release assays for detection of Mycobacterium tuberculosis infection. Clin Microbiol Rev. 2014;27(1):3-20.
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  4. CDC. TB Elimination. Available from: https://www.cdc.gov/tb/publications/factsheets/testing/IGRA.pdf. Accessed on Jan 14, 2019
  5. Gupta KB. Challenges in diagnosis and treatment of latent tuberculosis infection. Indian J Tuber 2012: 59:1-5.
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