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VOLUME 1 , ISSUE 1 ( January-March, 2019 ) > List of Articles


Mendelian Susceptibility to Mycobacterial Disease: A Clinical and Laboratory Approach

Keywords : Disseminated BCG infection, Interferon, Mycobacterial disease

Citation Information : Mendelian Susceptibility to Mycobacterial Disease: A Clinical and Laboratory Approach. Pediatr Inf Dis 2019; 1 (1):34-36.

DOI: 10.5005/jp-journals-10081-1108

License: CC BY-NC 4.0

Published Online: 01-06-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Mendelian susceptibility to mycobacterial disease (MSMD) is a group of rare genetic disorders characterized by increased susceptibility to infections with low-virulent mycobacteria like the Bacillus Calmette-Guérin (BCG) vaccines and the nontubercular environmental mycobacteria. These patients are also at increased risk of infections with non-typhoidal Salmonella, Candida, and Mycobacterium tuberculosis. In this article, we provide a clinical and laboratory approach to the diagnosis of MSMD. Various genetic defects causing MSMD and their treatment have been discussed.

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