The risk of exposure to HIV is high among certain populations like healthcare personnel (HCP), injection drug users (IDUs) and people engaged in unprotected sex. The timely reporting of the needle stick injury or potential exposure to HIV depends on the knowledge and understanding of PEP by the HCP. There is a delay in development of systemic infection after the initial exposure caused by the HIV replication in the dendritic cells of the skin and mucosa before spread through the lymphatic vessels. This window of opportunity can be utilized to block the replication of HIV by providing PEP. The case control study has demonstrated the reduction in acquisition of HIV by 81% after introduction of PEP among HCPs. Hence a comprehensive review on PEP among HCP, particularly with reference to Indian context is presented here.
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