Pediatric Infectious Disease

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VOLUME 2 , ISSUE 1 ( January-March, 2020 ) > List of Articles

Immunology Corner

B-cell Defects: A Clinical and Immunological Approach

Citation Information : B-cell Defects: A Clinical and Immunological Approach. Pediatr Inf Dis 2020; 2 (1):36-38.

DOI: 10.5005/jp-journals-10081-1236

License: CC BY-NC 4.0

Published Online: 21-10-2020

Copyright Statement:  Copyright © 2020; The Author(s).


Primary immune deficiency diseases (PIDs), better known as inborn errors of immunity (IEIs), are a group of heterogeneous diseases with increased susceptibility to infections, autoimmunity, allergy, and malignancies, caused by a defect in the immune system. The latest classification on IEI by International Union of Immunological Societies (IUIS) has described around 416 IEIs. “Predominant antibody deficiencies” contribute to the largest group of IEIs in most of the published cohorts worldwide. B-cell defects/antibody deficiencies would be discussed in this paper, and the reader would be provided with a simplified clinical and immunological approach to these diseases.

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  1. Tangye SG, Al-Herz W, Bousfiha A, et al. Human inborn errors of immunity: 2019 Update on the classification from the International Union of Immunological Societies Expert Committee. J Clin Immunol 2020;40(1):24–64. DOI: 10.1007/s10875-019-00737-x.
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