Pediatric Infectious Disease

Register      Login

VOLUME 2 , ISSUE 2 ( April-June, 2020 ) > List of Articles


Acute Encephalopathy in a Child with Coronavirus Disease-2019 Infection

Aarti Kinikar, Rajesh Kulkarni, Uday Rajput, Rajesh Karyakarte

Citation Information : Kinikar A, Kulkarni R, Rajput U, Karyakarte R. Acute Encephalopathy in a Child with Coronavirus Disease-2019 Infection. Pediatr Inf Dis 2020; 2 (2):62-63.

DOI: 10.5005/jp-journals-10081-1244

License: CC BY-NC 4.0

Published Online: 01-09-2019

Copyright Statement:  Copyright © 2020; The Author(s).


Coronavirus disease-2019 (COVID-19) is a global health crisis. Children account for 1–5% of diagnosed COVID-19 cases with relatively mild presentation and less mortality compared to adults. While patients typically present with fever, shortness of breath, and cough, neurologic manifestations have been reported, mainly in adults. We report a case of COVID-19-associated encephalopathy in an 11-year-old child who presented with altered sensorium and seizures.

PDF Share
  1. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 Hospitalized patients with 2019 novel coronavirus infected pneumonia in Wuhan, china. JAMA 2020;323(11):1061–1069. DOI: 10.1001/jama.2020. 1585.
  2. Mao L, Wang M, Chen S, et al., Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study 2020.
  3. Rossi A. Imaging of acute disseminated encephalomyelitis. Neuroimaging Clin N Am 18(1):149–161. DOI: 10.1016/j.nic.2007. 12.007.
  4. Mehta P, McAuley DF, Brown M, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 2020;395(10229):1033–1034. DOI: 10.1016/S0140-6736(20)30628-0.
  5. Wong AM, Simon EM, Zimmerman RA, et al. Acute necrotizing encephalopathy of childhood: correlation of MR findings and clinical outcome. AJNR Am J Neuroradiol 2006;27(9):1919–1923.
  6. Clerkin KJ, Fried JA, Raikhelkar J, et al. Coronavirus disease 19 (COVID-19) and cardiovascular disease. Circulation 2020;141:1648–1655. DOI: 10.1161/CirculationAHA 120.046941.
  7. Zhang Y, Xiao M, Zhang S, et al. Coagulopathy and antiphospholipid antibodies in patients with COVID-19. N Engl J Med 2020;382(17):e38. DOI: 10.1056/NEJMc2007575.
  8. Jiang T, Gao L, Lu J, et al. ACE2-Ang-(1-7)-Mas axis in brain: a potential target for prevention and treatment of ischemic stroke. Curr Neuropharm 2013;11(2):209–217. DOI: 10.2174/1570159X11311020007.
  9. Balasubramaniam S, Nagendran T, Ramchandran B, et al. Hyper-inflammatory syndrome in a child with COVID-19 treated successfully with intravenous immunoglobulin and tocilizumab. Indian Pediatr 2020. Available from: Accessed June 09, 2020.
  10. Dugue R, Cay-Martínez KC, Thakur KT, et al. Neurologic manifestations in an infant with COVID-19. Neurology 2020;94(24):1100–1102. DOI: 10.1212/WNL.0000000000009653.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.