Pediatric Infectious Disease

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VOLUME 2 , ISSUE 3 ( July-September, 2020 ) > List of Articles

Original Article

Clinical Experience of Granulocyte Transfusion Therapy in Pediatric Patients for Management of Neutropenia-related Infections in a Tertiary Care Center in India

Sunil Bhat, Sohini Chakraborty, Pooja Mallya, Shobha Badiger, Prathip Kumar

Keywords : Granulocyte transfusion, Infections, India, Neutropenia, Pediatric patients

Citation Information : Bhat S, Chakraborty S, Mallya P, Badiger S, Kumar P. Clinical Experience of Granulocyte Transfusion Therapy in Pediatric Patients for Management of Neutropenia-related Infections in a Tertiary Care Center in India. Pediatr Inf Dis 2020; 2 (3):85-88.

DOI: 10.5005/jp-journals-10081-1262

License: CC BY-NC 4.0

Published Online: 25-11-2020

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction: In neutropenic patients bacterial and fungal infections are a major cause of morbidity and mortality, especially in hematological malignancies and post-hematopoietic stem cell transplantation. We present here a single institution experience with the use of granulocyte transfusions in children with severe neutropenic sepsis. Material and methods: This is a retrospective analysis of 48 children who received a total of 120 granulocyte transfusions following mobilization with colony-stimulating growth factor (G-CSF) and dexamethasone. Results: Favorable response was seen in 41.6% of the children without any major adverse effects in donor or recipient. Conclusion and clinical significance: Granulocyte transfusions hence may be a useful adjunct to antimicrobials and growth factors in neutropenic sepsis refractory to conventional antimicrobials.


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