Pediatric Infectious Disease

Register      Login

VOLUME 2 , ISSUE 3 ( July-September, 2020 ) > List of Articles

Immunology Corner

What are Autoinflammatory Diseases?

Citation Information : What are Autoinflammatory Diseases?. Pediatr Inf Dis 2020; 2 (3):122-124.

DOI: 10.5005/jp-journals-10081-1275

License: CC BY-NC 4.0

Published Online: 28-09-2020

Copyright Statement:  Copyright © 2020; The Author(s).


Autoinflammatory diseases/syndromes are a new group of heterogeneous diseases characterized by “spontaneous onset of inflammation with no evidence of infection, autoimmunity or allergy and occur due to a defect in the innate immune system.” With the advancement of molecular genetics and next-generation sequencing technologies, new diseases are being added to this list every year. In this review, a brief description of a few autoinflammatory diseases would be provided along with a clinical approach. Salient clinical features have been highlighted.

PDF Share
  1. Havnaer A, Han G. Autoinflammatory disorders: a review and update on pathogenesis and treatment. Am J Clin Dermatol 2019;20(4):539–564. DOI: 10.1007/s40257-019-00440-y.
  2. Vanoni F, Theodoropoulou K, Hofer M. PFAPA syndrome: a review on treatment and outcome. Pediatr Rheumatol 2016;14(1):38. DOI: 10.1186/s12969-016-0101-9.
  3. Caso F, Galozzi P, Costa L, et al. Autoinflammatory granulomatous diseases: from Blau syndrome and early-onset sarcoidosis to NOD2-mediated disease and Crohn's disease. RMD Open 2015;1(1):e000097. DOI: 10.1136/rmdopen-2015-000097.
  4. Buch K, Thuesen ACB, Brøns C, et al. Chronic non-bacterial osteomyelitis: a review. Calcif Tissue Int 2019;104(5):544–553. DOI: 10.1007/s00223-018-0495-0.
  5. Vanderver A, Adang L, Gavazzi F, et al. Janus kinase inhibition in the Aicardi-Goutières syndrome. N Engl J Med 2020;383(10):986–989. DOI: 10.1056/NEJMc2001362.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.