Pediatric Infectious Disease

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VOLUME 2 , ISSUE 4 ( October-December, 2020 ) > List of Articles

Original Article

Comparison of Profile and Sensitivity Patterns of Organism Causing Neonatal Sepsis between a Tertiary Care Neonatal Unit and DeNIS Study

Bharathi Balachander, Gouthami Muktineni, Suman Rao

Keywords : Infection, Multidrug-resistant, Neonate

Citation Information : Balachander B, Muktineni G, Rao S. Comparison of Profile and Sensitivity Patterns of Organism Causing Neonatal Sepsis between a Tertiary Care Neonatal Unit and DeNIS Study. Pediatr Inf Dis 2020; 2 (4):127-129.

DOI: 10.5005/jp-journals-10081-1258

License: CC BY-NC 4.0

Published Online: 20-02-2021

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Background: Infection is an important cause of mortality and morbidity in neonates. The rise in multidrug-resistant as reported by the Delhi Neonatal Infection Study (DeNIS) is alarmingly high. The aim of our study was to compare the results of the DeNIS with a single-center data from southern part of India Materials and methods: This is a prospective observational study conducted between January 2016 and December 2017 in a tertiary care neonatal unit. Infants with blood culture positive sepsis were included in the study. The data were compared to the DeNIS study. A p value of <0.05 was considered significant. Results: The commonest organism identified in our study was CONS (40%) followed by Klebsiella, E. coli, Candida, and non-fermenting gram-negative bacilli. The DeNIS collaboration identified Acinetobacter to be the commonest cause. Methicillin resistance prevailed in 70% of CONS and 50% Staphylococcus aureus isolates in our study compared to 61% and 38% in the DeNIS. In the gram-negative organism, MDR was 66% for Acinetobacter, 15% for E. coli, and 44% for Klebsiella. In the DeNIS, the rates of resistance were 82%, 54%, and 38% for Acinetobacter, E. coli, and Klebsiella, respectively. The mortality in MDRO was 26.9% compared to 15.7% in Denis. Conclusion: Our findings conclude that the incidence of sepsis was similar to the DeNIS study, and antimicrobial resistance and the mortality secondary to the same is high. Unlike the DeNIS collaboration, the incidence of Acinetobacter was lower in our center. A nation-wide multicentric study on the profile of infection in neonates and antibiotic sensitivity is the need of the hour.

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