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VOLUME 2 , ISSUE 4 ( October-December, 2020 ) > List of Articles


Nutritionally Acquired Immunodeficiency Syndrome: An Interaction of Nutrition, Infection, and Immunity

Kandathil Eapen Elizabeth

Keywords : Immunity, Infection, Malnutrition, Nutrition, Nutritionally acquired immune deficiency syndrome

Citation Information : Elizabeth KE. Nutritionally Acquired Immunodeficiency Syndrome: An Interaction of Nutrition, Infection, and Immunity. Pediatr Inf Dis 2020; 2 (4):140-145.

DOI: 10.5005/jp-journals-10081-1269

License: CC BY-NC 4.0

Published Online: 20-02-2021

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Nutritionally acquired immune deficiency syndrome (NAIDS) is a significant disadvantage to children with malnutrition. The role of nutrients in immunity and markers of inflammation in infections are highlighted. The complex interaction between malnutrition, infection, and immunity are elucidated. A brief note on the “ABCDEFG approach” for comprehensive assessment and nutrient supplementation for optimum intervention is included.

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  1. Rodgers E. Nutritionally acquired immune deficiency syndromes (NAIDS): common but often not diagnosed early. Pac Health Dialog 2011;17(1):149–153.
  2. Beisel WR. Nutrition in pediatric HIV infection: setting the research agenda. Nutrition and immune function: overview. J Nutr 1996;126(10 Suppl):2611S–2615S. DOI: 10.1093/jn/126.suppl_10.2611S.
  3. Anurag B. Undernutrition, nutritionally acquired immunodeficiency, and tuberculosis control. BMJ 2016;355:i5407.
  4. Caulfield LE, de Onis M, Blössner M, et al. Undernutrition as an underlying cause of child deaths associated with diarrhea, pneumonia, malaria, and measles. Am J Clin Nutr 2004;80(1):193–198. DOI: 10.1093/ajcn/80.1.193pmid:15213048.
  5. Chandra RK. Nutrition and immunity: lessons from the past and new insights into the future. Am J Clin Nutr 1991;53(5):1087–1101. DOI: 10.1093/ajcn/53.5.1087.
  6. Wu D, Lewis ED, Pae M, et al. Nutritional modulation of immune function: analysis of evidence, mechanisms, and clinical relevance. Front Immunol 2019;9:3160. DOI: 10.3389/fimmu.2018.03160.
  7. Kaminogawa S, Nanno M. Modulation of immune functions by foods. Evid Based Complement Alternat Med 2004;1(3):241–250. Published online 2004 Oct 6 10.1093/ecam/neh042PMCID: PMC538513.
  8. Calder PC, Carr CA, Gombart AF. Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections. Nutrients 2020;12(4):1181.
  9. Cooper EL, Ma MJ. Understanding nutrition and immunity in disease management. J Tradit Complement Med 2017;7(4):386–391. Published online 2017 Jan 16 10.1016/j.jtcme.2016.12.002.
  10. Vasquez-Garibay E, Campollo-Rivas O, Romero-Velarde E, et al. Effect of renutrition on natural and cell-mediated immune response in infants with severe malnutrition. J Pediatr Gastroenterol Nutr 2002;34(3):296–301. DOI: 10.1097/00005176-200203000-00015.
  11. Castle SC. Clinical relevance of age-related immune dysfunction. Clin Infect Dis 2000;31(2):578–585. DOI: 10.1086/313947.
  12. Wilson N, Pedersen S. Inflammatory markers in clinical practice. Am J Respir Crit Care Med 2000;162(2 Pt 2):S48–S51. DOI: 10.1164/ajrccm.162.supplement_1.maic-13.
  13. Amati L, Cirimele D, Pugliese V, et al. Nutrition and immunity: laboratory and clinical aspects. Curr Pharm Des 2003;9(24):1924–1931. DOI: 10.2174/1381612033454252.
  14. Prasad AS. Effects of zinc deficiency on Th1 and Th2 cytokine shifts. J Infect Dis 2000(182 Suppl 1):S62–S68. DOI: 10.1086/315916.
  15. Houdjik APJ, Rijnsburger ER, Jansen J, et al. Randomized trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Lancet 1998;352(9130):772–776. DOI: 10.1016/S0140-6736(98)02007-8.
  16. Song JX, Qing SH, Huang XC, et al. Effect of parenteral nutrition with L-arginine supplementation on postoperative immune function in patients with colorectal cancer. Di Yi Jun Yi Da Xue Xue Bao 2002;22(6):545–547.
  17. Braga M, Gianotti L, Vignali A, et al. Preoperative oral arginine and n-3 fatty acid supplementation improves the immunometabolic host response and outcome after colorectal resection for cancer. Surgery 2002;132(5):805–814. DOI: 10.1067/msy.2002.128350.
  18. Elizabeth KE. Protein energy malnutrition and severe acute malnutrition. In: Elizabeth KE, ed. Nutrition and Child Development. 5th ed., Hyderabad: Paras Medical Publisher; 2015. pp. 186–241.
  19. Elizabeth KE. Locally available and natural therapeutic foods for immunomodulation in protein energy malnutrition. Indian J Med Res 2007;126(3):179–181.
  20. Field CJ, Johnson IR, Schley PD. Nutrients and their role in host resistance to infection. J Leukocyte Biol 2002;71(1):16–32.
  21. Elizabeth KE. Crusade against malnutrition: nutrition education Programme. Indian Pediatr 2016;53(3):203–206. DOI: 10.1007/s13312-016-0820-5.
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