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VOLUME 2 , ISSUE 4 ( October-December, 2020 ) > List of Articles

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Respiratory Syncytial Virus

Mallavalli Surendranath

Keywords : Monoclonal antibody palivizumab, Respiratory infection, Respiratory syncytial virus, Respiratory syncytial virus protein F

Citation Information : Surendranath M. Respiratory Syncytial Virus. Pediatr Inf Dis 2020; 2 (4):146-151.

DOI: 10.5005/jp-journals-10081-1272

License: CC BY-NC 4.0

Published Online: 20-02-2021

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Respiratory syncytial virus (RSV) is one of most common cause of lower respiratory tract infection in infants less than 2 years of age and sometimes in elderly people. Bronchiolitis is the common presentation. Severe infection is seen in high-risk infants and preterm infants. More than 90% of mortality due to RSV infection occurs in developing countries. At present, no specific drug is available for treatment. Prevention of RSV infection can be done by giving palivizumab, which is a monoclonal antibody developed against RSV fusion protein. Phase 3 clinical trials are done with nanoparticle RSV protein F vaccine for pregnant mothers to protect the infant through transplacental transfer of RSV antibodies. Clinical trials are going on for live attenuated RSV vaccine, vector-based vaccines, chimeric vaccine, and subunit vaccine.


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