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VOLUME 2 , ISSUE 4 ( October-December, 2020 ) > List of Articles

Notes From The Lab

Decoding Laboratory Diagnosis of Mycoplasma pneumoniae

Aruna Poojary

Citation Information : Poojary A. Decoding Laboratory Diagnosis of Mycoplasma pneumoniae. Pediatr Inf Dis 2020; 2 (4):158-160.

DOI: 10.5005/jp-journals-10081-1279

License: CC BY-NC 4.0

Published Online: 01-12-2020

Copyright Statement:  Copyright © 2020; The Author(s).


Mycoplasma pneumoniae contributes to 30–40% of community-acquired pneumonia in children and has the potential to cause clusters and outbreaks in closed settings. Early diagnosis helps in appropriate management of the case and also reduces long-term complications associated with extrapulmonary disease. Molecular testing and specific serology remain the backbone of laboratory diagnosis for Mycoplasma pneumoniae.

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  1. Atkinson TP, Balish MF, Waites KB. Epidemiology, clinical manifestations, pathogenesis and laboratory detection of Mycoplasma pneumoniae infections. FEMS Microbiol Rev 2008;32(6):956–973. DOI: 10.1111/j.1574-6976.2008.00129.x.
  2. Waites KB, Xiao L, Paralanov V, et al. Molecular methods for the detection of Mycoplasma and Ureaplasma infections in humans: a paper from the 2011 William Beaumont hospital symposium on molecular pathology. J Molecul Diagnost 2012;14(5):437–450. DOI: 10.1016/j.jmoldx.2012.06.001.
  3. Waites KB, Talkington DF. Mycoplasma pneumoniae and its role as a human pathogen. Clin Microbiol Rev 2004;17(4):697–728. DOI: 10.1128/CMR.17.4.697-728.2004.
  4. Søndergaard MJ, Friis MB, Hansen DS, et al. Clinical manifestations in infants and children with Mycoplasma pneumoniae infection. PLoS ONE 2018;13(4):e0195288. DOI: 10.1371/journal.pone. 0195288.
  5. Waites KB, Xiao L, Liu Y, et al. Mycoplasma pneumoniae from the respiratory tract and beyond. Clin Microbiol Rev 2017;30(3):747–809. DOI: 10.1128/CMR.00114-16.
  6. Narita M. Pathogenesis of extrapulmonary manifestations of Mycoplasma pneumoniae infection with special reference to pneumonia. J Infect Chemother 2010;16(3):162–169. DOI: 10.1007/s10156-010-0044-x.
  7. Daxboeck F, Krause R, Wenisch C. Laboratory diagnosis of Mycoplasma pneumoniae infection. Clin Microbiol Infect 2003;9(4):263–273. DOI: 10.1046/j.1469-0691.2003.00590.x.
  8. Loens K, Goossens H, Ieven M. Acute respiratory infection due to Mycoplasma pneumoniae: current status of diagnostic methods. Eur J Clin Microbiol Infect Dis 2010;29:1055–1069. DOI: 10.1007/s10096-010-0975-2.
  9. Thurman KA, Walter ND, Schwartz SB, et al. Comparison of laboratory diagnostic procedures for detection of Mycoplasma pneumoniae in community outbreaks. Clin Infect Dis 2009;48(9):1244–1249. DOI: 10.1086/597775.
  10. Miyashita N, Kawai Y, Tanaka T, et al. Diagnostic sensitivity of a rapid antigen test for the detection of Mycoplasma pneumoniae: comparison with real-time PCR. J Infect Chemother 2015;21(6):473–475. DOI: 10.1016/j.jiac.2015.02.007.
  11. Kumar S. Mycoplasma pneumoniae: a significant but underrated pathogen in paediatric community-acquired lower respiratory tract infections. Indian J Med Res 2018;147(1):23–31. DOI: 10.4103/ijmr.IJMR_1582_16.
  12. Wijesooriya W, Sunil-Chandra N, Perera J. Reliability of cold agglutinin test (CAT) for the detection of patients with Mycoplasma pneumoniae pneumonia. Sri Lankan J Infect Dis 2016;6:25. DOI: 10.4038/sljid.v6i1.8099.
  13. Swiecicki PL, Hegerova LT, Gertz MA. Cold agglutinin disease. Blood 2013;122(7):1114–1121. DOI: 10.1182/blood-2013-02-474437.
  14. Khan FY, Yassin. MA. Mycoplasma pneumoniae associated with severe autoimmune hemolytic anemia: case report and literature review. Braz J Infect Dis 2009;13(1):77–79. DOI: 10.1590/S1413-86702009000100018.
  15. Alves Vervloet L, Marguet C, Augusto P, et al. Infection by Mycoplasma pneumoniae and its importance as an etiological agent in childhood community-acquired pneumonias. Braz J Infect Dis 2007;11(5):507–514. DOI: 10.1590/S1413-86702007000500012.
  16. Youn YS, Lee KY, Hwang JY, et al. Difference of clinical features in childhood Mycoplasma pneumoniae pneumonia. BMC Pediatr 2010;10(1):48. DOI: 10.1186/1471-2431-10-48.
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