Guillain-Barré syndrome (GBS) is a common cause of acute weakness in children; in the majority of cases, a preceding infection can be identified. There is increasing evidence that coronaviruses can affect the central nervous system and present with varied neurological manifestations. The clinicians must be aware of the neuroinvasive properties of SARS-CoV-2 when caring for patients with COVID-19. We hereby report GBS in a toddler as a rare neurological manifestation of COVID-19.
Roodbol J, Kahlmann V, Drenthen J, et al. Diagnosis of Guillain-Barré syndrome in children and validation of the Brighton criteria. J Neurol 2017;264(5):856–861. DOI: 10.1007/s00415-017-8429-8
WHO, 2020 covid - Google Search [Internet]. [cited 2021]; Available from: https://www.google.com/search?client=firefox-b-d&q=WHO%2C + 2020+covid
Bodro M, Compta Y, Sánchez-Valle R. Presentations and mechanisms of CNS disorders related to Covid-19. Neurol Neuroimmunol Neuroinflamm 2021;8(1). DOI: 10.1212/NXI.0000000000000923
Zhao H, Shen D, Zhou H, et al. Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? Lancet Neurol 2020;19(5):383–384. DOI: 10.1016/s1474-4422(20)30109-5
Sharma S, Sood M. Current evidence on coronavirus disease-2019: a comprehensive review. Pediatr Infect Dis 2021;3(2):65–73. DOI: 10.5005/jp-journals-10081-1286
Mancera-Páez O, Román GC, Pardo-Turriago R, et al. Concurrent Guillain-Barré syndrome, transverse myelitis and encephalitis post-Zika: a case report and review of the pathogenic role of multiple arboviral immunity. J Neurol Sci 2018;395:47–53. DOI: 10.1016/j.jns.2018.09.028
Shoraka S, Ferreira MLB, Mohebbi SR, et al. SARS-CoV-2 infection and Guillain-Barré syndrome: a review on potential pathogenic mechanisms. Front Immunol 2021;12:674922. DOI: 10.3389/fimmu.2021.674922
