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VOLUME 4 , ISSUE 4 ( October-December, 2022 ) > List of Articles

Immunology Corner

Autoimmunity and Inborn Errors of Immunity: Two Faces of the Same Coin!

Neha Singh, Sagar Bhattad

Keywords : Autoimmunity, Immune deficiency, Immune dysregulation

Citation Information : Singh N, Bhattad S. Autoimmunity and Inborn Errors of Immunity: Two Faces of the Same Coin!. Pediatr Inf Dis 2022; 4 (4):153-155.

DOI: 10.5005/jp-journals-10081-1374

License: CC BY-NC 4.0

Published Online: 31-12-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Autoimmune disorders are a heterogeneous group of disorders characterized by immune dysregulation and are associated with a loss of tolerance to self-antigens. Autoimmunity in patients with inborn errors of immunity (IEI) has always been a puzzling phenomenon! Autoimmunity may be the first clinical presentation or sequel in patients with IEI. In this paper, we discuss the mechanisms of autoimmunity in IEI and present a few clinical cases highlighting the need to consider an IEI in patients presenting with autoimmunity and infections, polyautoimmunity, and polyendocrinopathy.


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  2. Bousfiha A, Jeddane L, Picard C, et al. Human inborn errors of immunity: 2019 update of the IUIS phenotypical classification. J Clin Immunol 2020;40(1):66–81. DOI: 10.1007/s10875-020-00758-x
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