Pediatric Infectious Disease

Register      Login

VOLUME 5 , ISSUE 1 ( January-March, 2023 ) > List of Articles


Disseminated BCG Infection in Immunocompromised Child: A Case Report

H Chandrashekar, Basavaraja Gangasamudra Veerappa, Nijaguna Nangundappa, Prahalad Kumar Appadorai, Sanjay K Shivappa

Keywords : BCG adenitis, BCG vaccine, Primary immunodeficiency, Severe combined immunodeficiency (SCID)

Citation Information : Chandrashekar H, Veerappa BG, Nangundappa N, Appadorai PK, Shivappa SK. Disseminated BCG Infection in Immunocompromised Child: A Case Report. Pediatr Inf Dis 2023; 5 (1):25-26.

DOI: 10.5005/jp-journals-10081-1368

License: CC BY-NC 4.0

Published Online: 15-04-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Bacillus Calmette-Guérin (BCG) is a live bacterial vaccine of Mycobacterium bovis to prevent tuberculosis (TB). It is given at birth or as early as possible according to the national immunization schedule. Usually, BCG is well tolerated. Severe adverse events following BCG vaccinations include local abscess, ulceration, and suppurative abscess. Disseminated BCGosis is the most devastating adverse event with a high fatality rate. It is seen most commonly in infants with primary immunodeficiencies or infants born with human immunodeficiency virus (HIV) infection. Here we present a 7-month female child who presented initially with BCG adenitis and was later diagnosed with disseminated mycobacterial infection; hence investigated, and the diagnosis was confirmed as severe combined immunodeficiency (SCID).

  1. Balasubramanian S, Shastri DD, Chatterjee P, et al. IAP Guidebook on Immunization 2018-2019: By advisory committee on vaccines & immunization practices (ACVIP). 3rd Balasubramanian S, Shastri DD, Shah AK, Chatterjee P, Pemde HK, Shivananda S, et al., editors. New Delhi, India: Jaypee Brothers Medical; 2019.
  2. Rezai MS, Khotaei G, Mamishi S, et al. Disseminated Bacillus Calmette-Guerin infection after BCG vaccination. J Trop Pediatr 2008;54(6):413–416. DOI: 10.1093/tropej/fmn053
  3. Norouzi S, Aghamohammadi A, Mamishi S, et al. Bacillus Calmette-Guérin (BCG) complications associated with primary immunodeficiency diseases. J Infect 2012;64(6):543–554. DOI: 10.1016/j.jinf.2012.03.012
  4. Govindarajan KK, Chai FY. BCG adenitis-need for increased awareness. Malays J Med Sci 2011;18(2):66–69.
  5. Shahmohammadi S, Saffar MJ, Rezai MS. BCG-osis after BCG vaccination in immunocompromised children: case series and review. J Pediatr Rev 2014;2(1):47–54. DOI: 10.7508/JPR-V2-N1-62-74
  6. Ong RYL, Chan SWB, Chew SJ, et al. Disseminated Bacillus-Calmette-Guérin infections and primary immunodeficiency disorders in Singapore: a single center 15-year retrospective review. Int J Infect Dis 2020;97:117–125. DOI: 10.1016/j.ijid.2020.05.117
  7. Bhattad S. Mendelian susceptibility to Mycobacterial disease: a clinical and laboratory approach. Pediatr Inf Dis 2019;1(1):34–36. DOI: 10.5005/jp-journals-10081-1108
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.