Pediatric Infectious Disease

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VOLUME 5 , ISSUE 4 ( October-December, 2023 ) > List of Articles

Original Article

Demographic and Diagnostic Predictors of Respiratory Syncytial Virus in Children of Less than 2 Years Presenting with Acute Respiratory Tract Infection

Nikhil Raj, Priyanka Gupta, Dipti Agarwal, Jyotsna Agarwal, Jaya Garg

Keywords : Acute lower respiratory infection, Children, Respiratory syncytial virus, Reverse transcription polymerase chain reaction

Citation Information : Raj N, Gupta P, Agarwal D, Agarwal J, Garg J. Demographic and Diagnostic Predictors of Respiratory Syncytial Virus in Children of Less than 2 Years Presenting with Acute Respiratory Tract Infection. Pediatr Inf Dis 2023; 5 (4):109-113.

DOI: 10.5005/jp-journals-10081-1405

License: CC BY-NC 4.0

Published Online: 14-12-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Abstract

Background: Worldwide respiratory syncytial virus (RSV) is one of the leading infectious causes of acute respiratory tract infection (ARTI) and related death in children under the age of 2 and it accounts for 60–80% of bronchiolitis presentations in developing countries like India. The present study was done to determine the diagnostic and demographic predictors of RSV in children <2 years old who presented with ARTI. Materials and methods: This was a pilot study that was performed over a period of 18 months in a tertiary healthcare facility in Northern India. A total of 55 nasopharyngeal swab samples from cases with ARTI presentation were collected in viral transport media (VTM) and were tested for RSV using reverse transcription polymerase chain reaction (RT-PCR). Result: A total of 55 clinically suspected cases of ARTI with age <2 years, eight (14.5%) cases were positive for RSV RT-PCR, male gender, ear discharge, risk factors such as premature birth, bottle feeding, and chest X-ray findings such as hyperinflation had a significant association with children with RSV (p < 0.05) which can be used as diagnostic predictors for RSV during the study period peak of RSV cases occurred in between November and December (winter season). Conclusion: Diagnostic predictors are very important in identifying RSV in resource-limited countries like India where an expensive, technically cumbersome, and complex molecular confirmatory test is not possible. This study identifies a set of risk factors, demographic characteristics, and radiological findings that will guide clinicians to start management for RSV.


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