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VOLUME 1 , ISSUE 1 ( January-March, 2019 ) > List of Articles


Utility of Mantoux and Interferon-gamma Release Assays

Dhanya Dharmapalan

Keywords : Mantoux, Interferon-gamma release assays, Tuberculosis

Citation Information : Dharmapalan D. Utility of Mantoux and Interferon-gamma Release Assays. Pediatr Inf Dis 2019; 1 (1):17-18.

DOI: 10.5005/jp-journals-10081-1104

License: CC BY-NC 4.0

Published Online: 01-10-2019

Copyright Statement:  Copyright © 2019; The Author(s).


India has the highest burden of tuberculosis (TB). This article presents a review of the diagnostic utility and various limitations of the Mantoux and the interferon-gamma release assays (IGRA) tests in this high TB endemic setting. While both the tests cannot differentiate between latent and active TB, recent guidelines from WHO strongly recommends against the use of IGRA as an alternative to Mantoux test for India.

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  1. Central Tuberculisis Division, GOI. National Guidelines in treatment and management of Pediatric Tuberculosis. Available from: Accessed on Jan 10, 2019.
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  3. WHO. Report of WHO Expert Group on use of interferon-c release assays(IGRAs) in tuberculosis control in low-and-middle-income setting, 20–21 July, 2010. Accessed on Jan 10, 2019
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