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VOLUME 1 , ISSUE 2 ( April-June, 2019 ) > List of Articles
Shyam Kukreja, Tapisha Gupta
Keywords : Blood culture, Drug-resistant typhoid, Enteric fever, Indian report
Citation Information : Kukreja S, Gupta T. Cephalosporin-resistant Typhoid Fever: A Report of Two Cases with a Unique Isolate from a Tertiary Care Hospital in Delhi. Pediatr Inf Dis 2019; 1 (2):70-71.
License: CC BY-NC 4.0
Published Online: 01-12-2016
Copyright Statement: Copyright © 2019; The Author(s).
Typhoid fever is endemic in our country and is the commonest bacterial bloodstream infection in South Asia.1 Multidrug-resistant typhoid fever (MDRTF) is defined as typhoid fever caused by Salmonella enterica serovar Typhi strains (S. Typhi), which are resistant to the first-line recommended drugs, i.e., chloramphenicol, ampicillin, and trimethoprim–sulfamethoxazole. Extensively drug-resistant typhoid fever (XDRTF) is defined as Salmonella Typhi/Paratyphi resistant to first line antibiotics (ampicillin, chloramphenicol and cotrimoxazole) and also to fluoroquinolone and ceftriaxone. Pakistan has an ongoing epidemic of extensively drug resistant (XDR) typhoid, which is a cause for alarm. Prior to this XDR typhoid epidemic, which started in 2016, only 17 cases of ceftriaxone resistance were reported in the world literature. Four out of these 17 were cases of XDR typhoid reported in Iraq, Bangladesh, India, and Pakistan.2 We report two cases of cephalosporin resistant typhoid fever from North India in the pediatric age group and discuss the clinical presentation and treatment. These two isolates were resistant to four drugs (ampicillin, chloramphenicol, fluoroquinolone, and ceftriaxone) but sensitive to chloramphenicol.