Dengue virus infection (DVI), a tropical disease, caused by the bite of female Aedes aegypti and Aedes albopictus mosquitoes. The four distinct virus serotypes of the Flaviviridae family, DENV-1, DENV-2, DENV-3 and DENV-4, cause DVI. Dengue virus infection presents in different ways, ranging from a relatively innocuous flu-like dengue fever to severe dengue. Severe dengue fever is often associated with renal injury ranging from a mild and transient elevation of serum creatinine (SCr), proteinuria, erythrocyturia, dyselectrolytemia, glomerulonephritis, nephrotic syndrome to acute kidney injury (AKI). Acute kidney injury, an infrequent complication of dengue, is usually associated with hypotension, rhabdomyolysis, or hemolysis. Sadly, the existence of renal injury in DVI and its role in the outcome is rarely recognized in clinical practice. This review is to remind ourselves to this overlooked entity of renal manifestations of dengue infection in the tropics.
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