Current medical practice is seeing a rise of multidrug-resistant bacteria because of inappropriate antibiotic usage. New antibiotics discoveries are not at par with the rapidly developing drug resistance. To tide over these circumstances, old antibiotics are now being revived researched and assigned new roles. Antibiotics, such as colistin, nitrofurantoin, polymyxin, etc., are used in nosocomial and critical care setting to tackle the multidrug-resistant bacteria. Even the use of old antibiotics should be pathogen centered and inappropriate use should be avoided. In this study, we are trying to throw some light on some of the old antibiotics which are currently in use and their efficacy. A lot of research is still required to optimize the drug dosing and prevention of side effects of these older antibiotics.
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