Pediatric Infectious Disease

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VOLUME 3 , ISSUE 1 ( January-March, 2021 ) > List of Articles

REVIEW ARTICLE

Role of Laboratory in Diagnosing Fungal Infections

Liz Mary Paul, V Ajay

Citation Information : Paul LM, Ajay V. Role of Laboratory in Diagnosing Fungal Infections. Pediatr Inf Dis 2021; 3 (1):33-37.

DOI: 10.5005/jp-journals-10081-1294

License: CC BY-NC 4.0

Published Online: 01-03-2021

Copyright Statement:  Copyright © 2021; The Author(s).


Abstract

The laboratory plays a crucial role in diagnosing fungal infections that are often underdiagnosed. Identifying invasive fungal infections in the immunocompromised population requires a high index of suspicion and choice of diagnostic methods is of utmost importance. This article aims to describe the various methods in a nutshell and hence explain how an integrated approach helps in accurate diagnosis which will benefit the patient. It also illustrates a few interesting case reports along with their laboratory findings.


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  1. Retrieved from https://mycology.adelaide.edu.au/mycoses/.
  2. Seth R, Xess I, Jana M. Diagnosis of invasive fungal infections in children. Indian Pediatr 2019;56(3):229–236. DOI: 10.1007/s13312-019-1505-7.
  3. Wattier RL, Dvorak CC, Hoffman JA, et al. A prospective, international cohort study of invasive mold infections in children. J Pediatr Infect Dis Soc 2014;4(4):313–322. DOI: 10.1093/jpids/piu074.
  4. Kurade SM, Amladi SA, Miskeen AK. Skin scraping and potassium hydroxide mount. Indian J Dermatol Venereol Leprol 2006;72(3):238–241. DOI: 10.4103/0378-6323.25794.
  5. Abassi M, Boulware DR, Rhein J. Cryptococcal meningitis: diagnosis and management update. Curr Trop Med Rep 2015;2(2):90–99. DOI: 10.1007/s40475-015-0046-y.
  6. Azar MM, Hage CA. Laboratory diagnostics for histoplasmosis. J Clin Microbiol 2017;55(6):1612–1620. DOI: 10.1128/JCM.02430-16.
  7. Guarner J, Brandt ME. Histopathologic diagnosis of fungal infections in the 21st century. Clin Microbiol Rev 2011;24(2):247–280. DOI: 10.1128/CMR.00053-10.
  8. Hageage GJ, Harrington BJ, The use of calcofluor white in clinical mycology. Abstr 269 21st Interscience Conference on Antimicrobial Agents and Chemotherapy, 1981.
  9. Retrieved from https://mycology.adelaide.edu.au/descriptions/hyphomycetes/aspergillus/.
  10. Maxfield L, Matthews JJ, Ambrosetti DR, et al. Trichosporon fungemia in a pediatric patient with acute lymphoblastic leukemia. ID Cases 2015;2(4):106–108. DOI: 10.1016/j.idcr.2015.09.007.
  11. Al-Sweih N, Ahmad S, Joseph L, et al. Malassezia pachydermatis fungemia in a preterm neonate resistant to fluconazole and flucytosine. Med Mycol Case Rep 2014;5:9–11. DOI: 10.1016/j.mmcr.2014.04.004.
  12. Ghosh I, Raina V, Kumar L, et al. Serum galactomannan assay for diagnosis of probable invasive aspergillosis in acute leukemia and hematopoietic stem cell transplantation. Indian J Med Paediatr Oncol 2013;34(2):74–79. DOI: 10.4103/0971-5851.116181.
  13. Lamoth F. Galactomannan and 1,3-β-d-glucan testing for the diagnosis of invasive aspergillosis. J Fungi (Basel). 2016;2(3):22. DOI: 10.3390/jof2030022.
  14. Al-Juaid A, Al-Rezqi A, Almansouri W, et al. Pediatric gastrointestinal basidiobolomycosis: case report and review of literature. Saudi J Med Med Sci 2017;5(2):167–171.
  15. Wang Y, Li D, Qiao L, et al. Infant central nervous system aspergillosis with first-episode of intracranial hemorrhage: a case report. Medicine (Baltimore) 2017;96(47):e8893. DOI: 10.1097/MD.0000000000008893.
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