Pediatric Infectious Disease

Register      Login

VOLUME 4 , ISSUE 1 ( January-March, 2022 ) > List of Articles

Original Article

Clinicolaboratory Parameters of Pediatric COVID-19 Patients and Its Correlation with Outcome: A Study at a Teaching Hospital of Northern India

Anita Kumari, Preeti L Rai, Ruchika Bhatnagar, Prem L Prasad, Prakhar Gupta

Keywords : Biochemical parameters, Clinical features, ICU admission, Pediatric coronavirus disease 2019

Citation Information : Kumari A, Rai PL, Bhatnagar R, Prasad PL, Gupta P. Clinicolaboratory Parameters of Pediatric COVID-19 Patients and Its Correlation with Outcome: A Study at a Teaching Hospital of Northern India. Pediatr Inf Dis 2022; 4 (1):6-10.

DOI: 10.5005/jp-journals-10081-1327

License: CC BY-NC 4.0

Published Online: 08-02-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Aims and objectives: The worldwide prevalence of pediatric coronavirus disease-2019 (COVID-19) infections has risen from 1–5% in early part of 2020 to 8–9% in later half of 2020. Though clinical features of pediatric COVID-19 are well researched, its correlation with biochemical parameters and outcome is less evaluated. Materials and methods: A retrospective evaluation of records of a cohort of 45 children with RT-PCR confirmed COVID-19. We collected information on clinical, laboratory features, and their outcome in all children (age <18 years) admitted between March 1, 2020, and December 31, 2020. Results: The mean age of the study population was 11.7 ± 4.83 years. The average duration of hospital stay of patients was 7.8 ± 2.51 days. The majority of COVID-19 positive children were asymptomatic (20, 44.4%), 12 (26.6%) had upper respiratory tract features while only 4 (8.8%) had features of lower respiratory tract infection. Five children had nonspecific manifestations. The abnormal chest X-ray findings, the RFT, LFT, and inflammatory markers like C-reactive protein (CRP) (>1 mg/dL), lactate dehydrogenase (LDH) (>450 IU/L), serum ferritin (>300 ng/mL), and D-dimer values of >1,000 ng/mL, in ICU and non-ICU patients were highly significant. Conclusion: Coronavirus disease 2019 in Indian children seems to affect the older age group. In India, COVID-19 is more associated with comorbidities like chronic kidney disease and chronic infection like tuberculosis rather than congenital heart disease and other acute respiratory illnesses in western studies. Inflammatory markers correlate well with the severity of illness but TLC, DLC, and NL ratio showed variable results and does not correlate with severity of illness.

PDF Share
  1. Coronavirus disease (COVID19): Schools. World Health Organization. 2020 Sep 18.
  2. WHO COVID19 Dashboard 2021. 2021Apr 07.
  3. Graphical illustration of data from COVID19 cases in India, National Center for Disease Control (NCDC) 2020. Ministry of Health and Family, Government of India.
  4. VDV Coronavirus disease 2019. Caring for children. Accessed on 28th May, 2020.
  5. Fakiri ELK, Nassih H, Sab Ait I, et al. Epidemiology and clinical features of coronavirus disease 2019 in moroccan children. Indian J Pediatr 2020;57(9):808–810. DOI: 10.1007/s13312-020-1958-8.
  6. Henry MB, Benoitb WS, Santos de Oliveir HM, et al. Maria helena santos de oliveira. Laboratory abnormalities in children with mild and severe coronavirus disease 2019 (COVID-19): a pooled analysis and review. Clin Biochem 2020;81:1–8. DOI: 10.1016/j.clinbiochem.2020.05.012.
  7. Clinical management protocol: COVID-19. Government of India Ministry of Health and Family Welfare Directorate General of Health Services (EMR Division) Version 5, 03.07.20.
  8. Dong Y, Mo X, Hu Y, et al., Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics. 2020 Mar. Available from Accessed on April 04, 2020.
  9. Götzinger F, Santiago-García B, Noguera-Julián A, et al. COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study. Lancet Child Adolesc Health 2020;4(9):653–661. DOI: 10.1016/S2352-4642(20)30177-2.
  10. Corona virus Disease in Children - United States February 12-April 02 2020. Accessed on 28th May, 2020.
  11. Sarangi B, Reddy VS, Oswal JS, et al. Epidemiological and clinical characteristics of COVID-19 in Indian children in the initial phase of the pandemic. Indian J Pediatr 2020;57(10):914–917. DOI: 10.1007/s13312-020-1994-4.
  12. Shekerdemian LS, Mahmood NR, Wolfe KK, et al. Characteristics and outcomes of children with coronavirus disease 2019 (COVID-19) infection admitted to US and Canadian pediatric intensive care units. JAMA Pediatr 2020;174(9):868–873. DOI: 10.1001/jamapediatrics.2020.1948.
  13. Meena J, Yadav J, Saini L, et al. Clinical features and outcome of SARS-CoV-2 infection in children: a systematic review and meta-analysis. Indian Pediatr 2020;57(9):820–826. DOI: 10.1007/s13312-020-1961-0.
  14. Christophers B, Marin BG, Oliva R, et al. Trends in clinical presentation of children with COVID-19: a systematic review of individual participant data. Pediatr Res 2020. Online ahead of print 10.1038/s41390-020-01161-3.
  15. MoutchiaI J, Pokharel P, Kerri A, et al. Clinical laboratory parameters associated with severe or critical novel coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis. PLoS One 2020;15(10):e0239802. DOI: 10.1371/journal.pone.0239802.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.