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VOLUME 4 , ISSUE 3 ( July-September, 2022 ) > List of Articles


Transient Neonatal Cholestasis Secondary to Coagulase-negative Staphylococci Septicemia: A Case Report

Suneel K Kommineni, Singamala Rufus Rajkumar, Preethi Subramanian, Chitgupikar Sudharshan Raj

Keywords : Sepsis, Transient neonatal cholestasis, Ursodeoxycholic acid

Citation Information : Kommineni SK, Rajkumar SR, Subramanian P, Raj CS. Transient Neonatal Cholestasis Secondary to Coagulase-negative Staphylococci Septicemia: A Case Report. Pediatr Inf Dis 2022; 4 (3):111-113.

DOI: 10.5005/jp-journals-10081-1329

License: CC BY-NC 4.0

Published Online: 31-08-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Transient neonatal cholestasis (NC) is characterized by early-onset cholestasis and normalization of clinical and biochemical parameters at follow-up. The causes are multifactorial and include immature bile secretion (as in the case of prematurity) and other perinatal causes. Sepsis is responsible for 20% of cases of NC. It is mandatory to rule out other causes of NC before labeling the neonate as having transient NC. The use of ursodeoxycholic acid in cholestasis has been advocated to bring a faster decline in direct bilirubin levels in neonates. Neonates have to be evaluated early considering associated risk factors so that early intervention could prevent complications and yield better outcomes.

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