Pediatric Infectious Disease

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VOLUME 5 , ISSUE 3 ( July-September, 2023 ) > List of Articles

Immunology Corner

Lymphoproliferation: How do You Evaluate for an Immune Deficiency?

Neha Singh, Sagar Bhattad

Keywords : Immune dysregulation, Inborn errors of Immunity, Lymphoproliferation

Citation Information : Singh N, Bhattad S. Lymphoproliferation: How do You Evaluate for an Immune Deficiency?. Pediatr Inf Dis 2023; 5 (3):102-104.

DOI: 10.5005/jp-journals-10081-1397

License: CC BY-NC 4.0

Published Online: 29-09-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Lymphoproliferation (LP) refers to the excessive proliferation of lymphocytes, causing nodal and extranodal infiltration triggered by infection, malignancy, and inflammation. LP in patients with inborn errors of immunity (IEI) could have different connotations based on the type of IEI. When LP is the presenting complaint, the diagnosis of IEI is often delayed. In this article, we discuss LP as the key manifestation in patients with IEI and present a few clinical cases highlighting the different patterns of LP in IEI.

  1. Natkunam Y, Gratzinger D, Chadburn A, et al. Immunodeficiency-associated lymphoproliferative disorders: time for reappraisal? Blood 2018;132(18):1871–1878. DOI: 10.1182/blood-2018-04-842559
  2. Sharma S, Pilania RK, Anjani G, et al. Lymphoproliferation in inborn errors of immunity: the eye does not see what the mind does not know. Front Immunol 2022;13:856601. DOI: 10.3389/fimmu.2022.856601
  3. Migliavacca M, Assanelli A, Ponzoni M, et al. First occurrence of plasmablastic lymphoma in adenosine deaminase-deficient severe combined immunodeficiency disease patient and review of the literature. Front Immunol 2018;9:113. DOI: 10.3389/fimmu.2018.00113
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