Background: Worldwide respiratory syncytial virus (RSV) is one of the leading infectious causes of acute respiratory tract infection (ARTI) and related death in children under the age of 2 and it accounts for 60–80% of bronchiolitis presentations in developing countries like India. The present study was done to determine the diagnostic and demographic predictors of RSV in children <2 years old who presented with ARTI. Materials and methods: This was a pilot study that was performed over a period of 18 months in a tertiary healthcare facility in Northern India. A total of 55 nasopharyngeal swab samples from cases with ARTI presentation were collected in viral transport media (VTM) and were tested for RSV using reverse transcription polymerase chain reaction (RT-PCR). Result: A total of 55 clinically suspected cases of ARTI with age <2 years, eight (14.5%) cases were positive for RSV RT-PCR, male gender, ear discharge, risk factors such as premature birth, bottle feeding, and chest X-ray findings such as hyperinflation had a significant association with children with RSV (p < 0.05) which can be used as diagnostic predictors for RSV during the study period peak of RSV cases occurred in between November and December (winter season). Conclusion: Diagnostic predictors are very important in identifying RSV in resource-limited countries like India where an expensive, technically cumbersome, and complex molecular confirmatory test is not possible. This study identifies a set of risk factors, demographic characteristics, and radiological findings that will guide clinicians to start management for RSV.